Current molecular approaches to investigate pre?synaptic dysfunction

Over the course of last few decades it has become clear that many neurodevelopmental and neurodegenerative disorders have a synaptic defect, which contributes to pathogenicity. A rise in new techniques, particular '-omics'-based methods providing large datasets, led an increase potential proteins pathways implicated function related disorders. Additionally, advancements imaging techniques recent discovery alternative modes vesicle recycling. This resulted lack clarity over precise role different maintaining whether these are dysfunctional greater understanding molecular detail pre-synaptic health disease is key targeting for novel treatments variety currently available provides ideal opportunity investigate functions. review focuses on interrogate function, concentrating mainly It further examines determine underlying mechanism dysfunction discusses identify targets, along with protein–protein interactions cellular localization. In combination, will provide expanding more complete picture function. With application technological advances, we able resolve events higher spatial temporal resolution, leading research towards at presynapse plays